Metabolic rewiring of the hypertensive kidney

Markus M. Rinschen; Oleg Palygin; Carlos Guijas; Amelia Palermo; Nicolas Palacio-Escat; Xavier Domingo-Almenara; Rafael Montenegro-Burke; Julio Saez-Rodriguez; Alexander Staruschenko; Gary Siuzdak

doi:10.1126/scisignal.aax9760

Research ResourcePhysiology

Metabolic rewiring of the hypertensive kidney

View ORCID ProfileMarkus M. Rinschen ¹,²,
View ORCID ProfileOleg Palygin³,
View ORCID ProfileCarlos Guijas¹,
View ORCID ProfileAmelia Palermo¹,
View ORCID ProfileNicolas Palacio-Escat⁴,⁵,⁶,
View ORCID ProfileXavier Domingo-Almenara¹,
View ORCID ProfileRafael Montenegro-Burke¹,
View ORCID ProfileJulio Saez-Rodriguez⁴,⁵,⁷,
View ORCID ProfileAlexander Staruschenko³,⁸,*, and
View ORCID ProfileGary Siuzdak¹,*

¹Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.
²Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Cologne 50931, Germany.
³Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
⁴COMBINE-Joint Research Center for Computational Biomedicine RWTH Aachen University, Aachen 52074, Germany.
⁵Institute of Computational Biomedicine, Bioquant, Faculty of Medicine and Heidelberg University Hospital, Heidelberg University, Heidelberg 69120, Germany.
⁶Faculty of Biosciences, University of Heidelberg, Heidelberg 69120, Germany.
⁷Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory and Heidelberg University, Heidelberg 69120, Germany.
⁸Clement J. Zablocki VA Medical Center, Milwaukee, WI 53295, USA.

↵*Corresponding author. Email: staruschenko{at}mcw.edu (A.S.); siuzdak{at}scripps.edu (G.S.)

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Science Signaling 10 Dec 2019:
Vol. 12, Issue 611, eaax9760
DOI: 10.1126/scisignal.aax9760

Markus M. Rinschen

1Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.

2Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Cologne 50931, Germany.

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ORCID record for Markus M. Rinschen

Oleg Palygin

3Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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ORCID record for Oleg Palygin

Carlos Guijas

1Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.

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Amelia Palermo

1Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.

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ORCID record for Amelia Palermo

Nicolas Palacio-Escat

4COMBINE-Joint Research Center for Computational Biomedicine RWTH Aachen University, Aachen 52074, Germany.

5Institute of Computational Biomedicine, Bioquant, Faculty of Medicine and Heidelberg University Hospital, Heidelberg University, Heidelberg 69120, Germany.

6Faculty of Biosciences, University of Heidelberg, Heidelberg 69120, Germany.

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Xavier Domingo-Almenara

1Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.

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Rafael Montenegro-Burke

1Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.

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Julio Saez-Rodriguez

4COMBINE-Joint Research Center for Computational Biomedicine RWTH Aachen University, Aachen 52074, Germany.

5Institute of Computational Biomedicine, Bioquant, Faculty of Medicine and Heidelberg University Hospital, Heidelberg University, Heidelberg 69120, Germany.

7Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory and Heidelberg University, Heidelberg 69120, Germany.

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Alexander Staruschenko

3Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

8Clement J. Zablocki VA Medical Center, Milwaukee, WI 53295, USA.

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For correspondence: staruschenko@mcw.edu siuzdak@scripps.edu

Gary Siuzdak

1Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, La Jolla, CA 92122, USA.

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For correspondence: staruschenko@mcw.edu siuzdak@scripps.edu

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