Contents
17 December 2019
Vol 12, Issue 612
Vol 12, Issue 612
Research Articles
- Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin
Doxorubicin-induced DNA damage promotes cancer cell migration downstream of eIF2α phosphorylation.
- Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β
TGF-β–dependent metabolic dysregulation contributes to lung fibrosis.
- Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors
The abundance and clustering patterns of inhibitory receptors on natural killer cells are genetically encoded.
Editors' Choice
- Distinguishing friend from foe
Toxin-stimulated immune signaling helps neonatal mice distinguish between harmless skin colonizers and potential pathogens.
Retraction
About The Cover
Online Cover This week features a Research Article that shows that DNA damage induced by the commonly used chemotherapeutic doxorubicin promotes the phosphorylation of the translation factor eIF2α, and that instead of inhibiting protein synthesis, this phosphorylation event promotes cancer cell migration. The image shows an artist's depiction of DNA damage. [Image: Christoph Burgstedt/shutterstock.com]
