Contents
07 January 2020
Vol 13, Issue 613
Vol 13, Issue 613
Research Articles
- Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion
Hereditary spastic paraplegia–associated mutations in a WASH complex component impair integrin-mediated cell adhesion.
- The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a
An accessory protein suppresses β-arrestin–dependent signaling and constitutive activity of the ghrelin receptor.
Review
- Cracking the context-specific PI3K signaling code
Different cellular and environmental contexts produce distinct biological outcomes for PI3K signaling.
About The Cover
Online Cover This week features a Research Article that shows that disease-associated mutations in strumpellin, a component of the WASH complex, which plays a role in endosomal sorting, impair cell adhesion and spreading by disrupting integrin recycling. The image shows actin (red) and nuclei (blue) in a human retinal pigment epithelial cell line in which strumpellin was knocked down by RNA interference. [Image: Lee et al./Science Signaling]
