Contents
04 February 2020
Vol 13, Issue 617
Vol 13, Issue 617
Focus
- Microbiome studies in the medical sciences and the need for closer multidisciplinary interplay
An upcoming conference focuses on more interplay between researchers and clinicians studying microbiota.
Research Articles
- The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC
PACRG can functionally substitute for the LUBAC adaptor subunit SHARPIN to stimulate NF-κB signaling.
- A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity
A conserved amino acid residue in the ligand binding site of class A GPCRs regulates receptor interactions with β-arrestin.
Research Resource
- Probing the mutational landscape of regulators of G protein signaling proteins in cancer
Cancer-associated mutations in RGS proteins impair their ability to inhibit G protein signaling.
Editors' Choice
- CDK7 stabilizes Yap
CDK7 promotes cell proliferation and tissue growth by protecting the transcriptional coactivator Yap from degradation.
About The Cover
Online Cover This week features a Research Article that shows that PACRG can functionally substitute for the LUBAC adaptor subunit SHARPIN to stimulate NF-κB signaling. The image shows the NF-κB subunit p65 (green), mitochondria (red), and nuclei (blue) in human neuroblastoma SH-SY5Y cells. [Image: Meschede et al./Science Signaling]
