Contents
Vol 13, Issue 619
Research Articles
- Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma
Kinome profiling of ovarian tumors reveals a way to treat patients and get a step ahead of drug resistance.
- Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells
The mechanisms by which excessive fluoride causes defects in tooth enamel mineralization are revealed.
Review
- SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases
Although mainly investigated as anticancer therapies, SMAC mimetics and RIPK inhibitors may fight chronic inflammation.
Editors' Choice
- Mechanosensing metabolically moves cancer cells
A stiff stroma triggers metabolic changes that support invasion and metastasis in pancreatic cancer cells.
About The Cover

Online Cover This week features a Research Article that identifies new targets for treating high-grade serous ovarian cancer. The image shows staining for the kinase MRCKA in tumor tissue from a patient. [Image: Kurimchak et al./Science Signaling]