Contents

Research Articles

• Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

  By Alison M. Kurimchak, Carlos Herrera-Montávez, Jennifer Brown, Katherine J. Johnson, Valerie Sodi, Nishi Srivastava, Vikas Kumar, Safoora Deihimi, Shane O’Brien, Suraj Peri, Gina M. Mantia-Smaldone, Angela Jain, Ryan M. Winters, Kathy Q. Cai, Jonathan Chernoff, Denise C. Connolly, James S. Duncan

  Science Signaling18 Feb 2020 Full AccessRestricted Access

  Kinome profiling of ovarian tumors reveals a way to treat patients and get a step ahead of drug resistance.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials

• Fluoride exposure alters Ca²⁺ signaling and mitochondrial function in enamel cells

  By Francisco J. Aulestia, Johnny Groeling, Guilherme H. S. Bomfim, Veronica Costiniti, Vinu Manikandan, Ariya Chaloemtoem, Axel R. Concepcion, Yi Li, Larry E. Wagner II, Youssef Idaghdour, David I. Yule, Rodrigo S. Lacruz

  Science Signaling18 Feb 2020 Full AccessRestricted Access

  The mechanisms by which excessive fluoride causes defects in tooth enamel mineralization are revealed.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials