Research ArticleCalcium signaling

Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells

See allHide authors and affiliations

Science Signaling  18 Feb 2020:
Vol. 13, Issue 619, eaay0086
DOI: 10.1126/scisignal.aay0086

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

How too much fluoride derails dentition

Excessive fluoride ingestion during childhood results in defective tooth enamel mineralization, which can lead to dental problems later in life. Aulestia et al. investigated the molecular mechanisms underlying fluorosis in enamel-forming cells isolated from rats and in an enamel cell line. Exposure of enamel cells to fluoride resulted in decreases in ER Ca2+ content and store-operated Ca2+ entry into the ER, reduced the expression of genes encoding ER stress–response proteins, and resulted in mitochondrial dysfunction. These effects were not seen in HEK-293 cells (which are derived from kidney epithelium). These data may explain how fluorosis affects Ca2+ homeostasis in enamel-forming cells and highlight cell type–specific stress responses.

View Full Text

Stay Connected to Science Signaling