Contents
Vol 13, Issue 624
Research Articles
- An atlas of human metabolism
An open-source, genome-scale human metabolic model and a web portal to explore the model are generated.
- Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production
TLR4-dependent proinflammatory cytokine production still occurs when the receptor is endocytosed.
Review
- RAS, wanted dead or alive: Advances in targeting RAS mutant cancers
New signaling insights level the playing field against the notoriously “undruggable” protein RAS.
Editors' Choice
- Destroying tumors with pyroptosis
Gasdermin E suppresses tumor growth by stimulating antitumor immunity in a pyroptosis-dependent manner.
About The Cover

Online Cover This week features a Research Article that describes an open-source, genome-scale, human metabolic model called Human1 and a web portal called Metabolic Atlas to explore the model. The image shows a screenshot from the "Nucleus" compartment. [Image: Metabolic Atlas]