An atlas of human metabolism

Jonathan L. Robinson; Pınar Kocabaş; Hao Wang; Pierre-Etienne Cholley; Daniel Cook; Avlant Nilsson; Mihail Anton; Raphael Ferreira; Iván Domenzain; Virinchi Billa; Angelo Limeta; Alex Hedin; Johan Gustafsson; Eduard J. Kerkhoven; L. Thomas Svensson; Bernhard O. Palsson; Adil Mardinoglu; Lena Hansson; Mathias Uhlén; Jens Nielsen

doi:10.1126/scisignal.aaz1482

Research ArticleMetabolism

An atlas of human metabolism

Jonathan L. Robinson ¹,²,*,
Pınar Kocabaş¹,²,*,
Hao Wang¹,³,⁴,*,
Pierre-Etienne Cholley⁴,*,
Daniel Cook¹,
Avlant Nilsson¹,
Mihail Anton⁴,
Raphael Ferreira¹,
Iván Domenzain ¹,²,
Virinchi Billa¹,
Angelo Limeta¹,
Alex Hedin¹,
Johan Gustafsson¹,²,
Eduard J. Kerkhoven¹,
L. Thomas Svensson⁴,
Bernhard O. Palsson⁵,⁶,⁷,
Adil Mardinoglu⁸,⁹,
Lena Hansson⁴,¹⁰,
Mathias Uhlén⁵,⁸,¹¹, and
Jens Nielsen¹,²,⁵,¹²,†

¹Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.
²Wallenberg Center for Protein Research, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.
³Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Kemivägen 10, SE-41258 Gothenburg, Sweden.
⁴Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.
⁵Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
⁶Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
⁷Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
⁸Department of Protein Science, Science for Life Laboratory, KTH–Royal Institute of Technology, SE-10044 Stockholm, Sweden.
⁹Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London WC2R 2LS, UK.
¹⁰Novo Nordisk Research Centre Oxford, Oxford OX3 7FZ, UK.
¹¹Wallenberg Center for Protein Research, KTH–Royal Institute of Technology, SE-10044 Stockholm, Sweden.
¹²BioInnovation Institute, Ole Maaløes Vej 3, DK-2200 Copenhagen, Denmark.

↵†Corresponding author. Email: nielsenj{at}chalmers.se

↵* These authors contributed equally to this work.

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Science Signaling 24 Mar 2020:
Vol. 13, Issue 624, eaaz1482
DOI: 10.1126/scisignal.aaz1482

Jonathan L. Robinson

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

2Wallenberg Center for Protein Research, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Pınar Kocabaş

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

2Wallenberg Center for Protein Research, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Hao Wang

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

3Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Kemivägen 10, SE-41258 Gothenburg, Sweden.

4Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Pierre-Etienne Cholley

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Daniel Cook

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Avlant Nilsson

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Mihail Anton

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Raphael Ferreira

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Iván Domenzain

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

2Wallenberg Center for Protein Research, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Virinchi Billa

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Angelo Limeta

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Alex Hedin

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Johan Gustafsson

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

2Wallenberg Center for Protein Research, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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Eduard J. Kerkhoven

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

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L. Thomas Svensson

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Bernhard O. Palsson

5Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

6Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

7Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

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Adil Mardinoglu

8Department of Protein Science, Science for Life Laboratory, KTH–Royal Institute of Technology, SE-10044 Stockholm, Sweden.

9Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London WC2R 2LS, UK.

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Lena Hansson

10Novo Nordisk Research Centre Oxford, Oxford OX3 7FZ, UK.

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Mathias Uhlén

5Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

8Department of Protein Science, Science for Life Laboratory, KTH–Royal Institute of Technology, SE-10044 Stockholm, Sweden.

11Wallenberg Center for Protein Research, KTH–Royal Institute of Technology, SE-10044 Stockholm, Sweden.

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Jens Nielsen

1Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

2Wallenberg Center for Protein Research, Chalmers University of Technology, Kemivägen 10, SE-41258 Gothenburg, Sweden.

5Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

12BioInnovation Institute, Ole Maaløes Vej 3, DK-2200 Copenhagen, Denmark.

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For correspondence: nielsenj@chalmers.se

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