31 March 2020
Vol 13, Issue 625

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that noncanonical NF-κB signaling enhances the survival of CAR T cells that express the costimulatory domain of 4-1BB. These data suggest that manipulation of this pathway in future CAR T cell designs may improve clinical benefit. The image is a scanning electron micrograph of T cells attacking a breast cancer cell (pink). [Image: Steve Gschmeissner/Science Source]