Contents
31 March 2020
Vol 13, Issue 625
Vol 13, Issue 625
Research Articles
- 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
Noncanonical NF-κB signaling enhances the survival of CAR T cells expressing the 4-1BB costimulatory domain.
- Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety
Calmodulin sequesters and inhibits KRAS4b by binding a lipid-modified region of the protein.
- Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Low intrinsic efficacy can explain the reduced side effects of apparently biased μ-opioid receptor agonists.
Editors' Choice
- The A-to-Z of influenza infection
Z-RNA produced by influenza virus stimulates necroptosis and activates neutrophils in infected tissue.
About The Cover
Online Cover This week features a Research Article that shows that noncanonical NF-κB signaling enhances the survival of CAR T cells that express the costimulatory domain of 4-1BB. These data suggest that manipulation of this pathway in future CAR T cell designs may improve clinical benefit. The image is a scanning electron micrograph of T cells attacking a breast cancer cell (pink). [Image: Steve Gschmeissner/Science Source]
