Research ArticleNeuroscience

Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke

See allHide authors and affiliations

Science Signaling  07 Apr 2020:
Vol. 13, Issue 626, eaay5686
DOI: 10.1126/scisignal.aay5686

Breaking down barriers

Stroke decreases the function of the microvascular endothelial cells in the blood-brain barrier. The resulting immune cell infiltration and solute leak exacerbate the neuronal death caused by ischemic injury. Ma et al. found that endothelial cell–specific ablation of the miR-15a/16-1 microRNA cluster protected mice from ischemic brain damage. Analysis of cultured microvascular endothelial cells showed that the miR-15a/16-1 cluster targeted the gene encoding the tight junction protein claudin-5, which is critical for the barrier function of these cells. These results suggest that antagonizing this microRNA cluster may prevent the breakdown of the blood-brain barrier that occurs after stroke.

View Full Text

Stay Connected to Science Signaling