Contents
28 April 2020
Vol 13, Issue 629
Vol 13, Issue 629
Focus
- DNA polymerase κ: Friend or foe?
The DNA polymerase Polκ mediates tumor cell escape from stress-induced senescence (Temprine et al., in 28 April 2020 issue).
Research Articles
- Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance
DNA polymerase κ mediates drug resistance in tumor cells through a mechanism that could be independent of mutagenesis.
- Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels
TRPV1-mediated release of ER Ca2+ is sufficient to activate the sensory ion channel ANO1.
Editors' Choice
- Hitching a ride on a cough?
A component of M. tuberculosis activates nociceptor neurons to induce coughing.
About The Cover
Online Cover This week features a Research Article that shows that TRPV1-initiated release of Ca2+ from the endoplasmic reticulum through IP3 type 1 receptors (IP3R1s) is sufficient to activate ANO1, a sensory ion channel that promotes nociception by dorsal root ganglion (DRG) neurons. The image shows overlapping clusters of ANO1 (blue), TRPV1 (green), and IP3R1s (red) in DRG neurons as visualized by STORM imaging. [Image: Shah et al./Science Signaling]
