28 April 2020
Vol 13, Issue 629

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that TRPV1-initiated release of Ca2+ from the endoplasmic reticulum through IP3 type 1 receptors (IP3R1s) is sufficient to activate ANO1, a sensory ion channel that promotes nociception by dorsal root ganglion (DRG) neurons. The image shows overlapping clusters of ANO1 (blue), TRPV1 (green), and IP3R1s (red) in DRG neurons as visualized by STORM imaging. [Image: Shah et al./Science Signaling]