Research ArticleIon Channels

Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels

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Science Signaling  28 Apr 2020:
Vol. 13, Issue 629, eaaw7963
DOI: 10.1126/scisignal.aaw7963

Boosting the Ca2+ signal for nociception

The Ca2+-activated Cl channel ANO1 promotes nociception, the perception of pain. The nonselective cation channel TRPV1 has been proposed to be the source of Ca2+ that activates ANO1, but the amount of Ca2+ that TRPV1 allows into pain-transmitting DRG neurons is thought to be insufficient to activate ANO1. Shah et al. found that TRPV1 triggered Ca2+ release from the ER through an IP3 receptor isoform. Imaging techniques showed that ANO1, TRPV1, and the IP3 receptor clustered in close proximity to each other in pain-transmitting DRG neurons. These results provide insight into the molecular mechanisms underlying nociception.

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