FocusCancer therapy

DNA polymerase κ: Friend or foe?

See allHide authors and affiliations

Science Signaling  28 Apr 2020:
Vol. 13, Issue 629, eabb2934
DOI: 10.1126/scisignal.abb2934

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

In this issue of Science Signaling, Temprine et al. report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway–targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.

View Full Text

Stay Connected to Science Signaling