Contents
05 May 2020
Vol 13, Issue 630
Vol 13, Issue 630
Research Articles
- Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway
Spinal delivery of Hsp90 inhibitors may make opioids safer and more effective.
- p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators
Increased glycolytic stress in cancer cells stimulates p53 production to maintain metabolic homeostasis.
Editors' Choice
- Tumor’s loss is clinician’s gain
A mutation in the epigenetic machinery creates a metabolic vulnerability in lung cancers.
About The Cover
Online Cover This week features a Research Article that shows how spinal delivery of Hsp90 inhibitors can enhance the efficacy of systemically administered opioids. The image shows synthetic opioid peptide–induced ERK phosphorylation (green) in lumbar spine tissue slices from mice treated intrathecally with vehicle (top) or an Hsp90 inhibitor (bottom). [Image: Duron et al./Science Signaling]
