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Cover story: Cell death on acid

Low extracellular pH suppresses RIPK1-dependent cell death

Gustoimages/Science Source
AMPing up cytotoxicity

The kinase AMPK mediates lytic granule organization in cytotoxic T cells

Zurli et al./Science Signaling
Free this week: Chaperones put the brakes on opioids

Spinal delivery of Hsp90 inhibitors may make opioids safer and more effective

Duron et al./Science Signaling

Contents

12 May 2020
Vol 13, Issue 631

Research Articles
- The death-inducing activity of RIPK1 is regulated by the pH environment
  
  By Kenta Moriwaki, Sakthi Balaji, Francis Ka-Ming Chan
  
  Science Signaling12 May 2020 Full AccessRestricted Access
  
  Low extracellular pH suppresses RIPK1-dependent cell death.
  
  Editor's Summary
  
  Abstract
  
  Full Text
  
  PDF
  
  Supplementary Materials
- Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells
  
  By Vanessa Zurli, Tommaso Montecchi, Raphael Heilig, Isabel Poschke, Michael Volkmar, Giuliana Wimmer, Gioia Boncompagni, Gabriele Turacchio, Mario Milco D’Elios, Giuseppe Campoccia, Nicoletta Resta, Rienk Offringa, Roman Fischer, Oreste Acuto, Cosima Tatiana Baldari, Anna Kabanova
  
  Science Signaling12 May 2020 Full AccessRestricted Access
  
  CD2-stimulated AMPK activation mediates lytic granule organization in cytotoxic T cells.
  
  Editor's Summary
  
  Abstract
  
  Full Text
  
  PDF
  
  Supplementary Materials
Editors' Choice
- CLUHing in mitochondria to starvation
  
  By Annalisa M. VanHook
  
  Science Signaling12 May 2020 Full AccessRestricted Access
  
  The RNA-binding protein CLUH helps reprogram hepatocyte mitochondria in response to starvation.
  
  Abstract
  
  Full Text

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that low extracellular pH suppresses cell death pathways dependent on the kinase RIPK1. The image shows the color changes that occur in litmus paper when dipped into solutions of varying pH. [Image: Gustoimages/Science Source]