Research ArticleCell Biology

A protein kinase A–regulated network encodes short- and long-lived cellular memories

See allHide authors and affiliations

Science Signaling  19 May 2020:
Vol. 13, Issue 632, eaay3585
DOI: 10.1126/scisignal.aay3585

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Remembering stress with PKA

A prior stress can prime organisms to successfully survive subsequent stresses. In yeast, the kinase PKA is inhibited by stress, resulting in changes in gene expression that mediate the general stress response. Using PKA inhibition as a mimic for stress, Jiang et al. examined how yeast encoded the memories of previous stresses. Short-term memory required metabolism of the sugar trehalose and was more sensitive to the amplitude of the stress than its duration. In contrast, long-term memory was sensitive to stress duration and required stress-induced transcription factors and the storage of messenger ribonucleoproteins in granules. These results show how yeast use PKA to “remember” previous exposures to stress in the short term or over a longer period of time.

View Full Text

Stay Connected to Science Signaling