Contents
02 June 2020
Vol 13, Issue 634
Vol 13, Issue 634
Research Articles
- The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
Inhibiting the kinase IRAK4 may suppress a multicellular autoinflammatory loop in patients with lupus.
- A G protein–biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers
A biased S1P1 agonist that preserves endothelial function without causing lymphopenia is identified.
Editors' Choice
- Therapeutic potential of EBV infection
Targeting MYC or factors that sustain its expression may turn EBV infection into a therapeutic tool for B cell lymphomas.
About The Cover
Online Cover This week features a Research Article that shows why inhibiting the kinase IRAK4 may effectively target the underlying pathology, rather than merely the symptoms, of the autoimmune disease lupus. The image shows periodic acid–Schiff staining in kidney sections from a mouse model of systemic lupus erythematosus. [Image: Corzo et al./Science Signaling]
