09 June 2020
Vol 13, Issue 635

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that fibrosis arising from kidney injury is triggered by a cellular transdifferentiation program known as endothelial-to-mesenchymal transition that results in metabolic reprogramming of tubular epithelial cells (see also the associated Focus). The image shows a kidney cross section from a mouse subjected to unilateral ureteral obstruction to induce kidney damage that has been labeled for endothelial (green) and mesenchymal (red) cell markers and nuclei (blue). [Image: Lovisa et al./Science Signaling]