Contents
09 June 2020
Vol 13, Issue 635
Vol 13, Issue 635
Focus
- The interdependence of renal epithelial and endothelial metabolism and cell state
A cascade of metabolic and endothelial and epithelial cell state changes contributes to kidney fibrosis (Lovisa et al. in 9 June 2020 issue).
Research Article
- Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis
Kidney injury triggers endothelial-epithelial cellular crosstalk that culminates in fibrosis.
Research Resource
- Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome
Multiomics analysis reveals the changes that occur in the extracellular matrix in the brains of Zika virus–infected newborns.
Editors' Choice
- Intimate encounters with Neisseria gonorrhoeae
Adhesion to host cells localizes gonococcal NO production to suppress epithelial exfoliation.
About The Cover
Online Cover This week features a Research Article that shows that fibrosis arising from kidney injury is triggered by a cellular transdifferentiation program known as endothelial-to-mesenchymal transition that results in metabolic reprogramming of tubular epithelial cells (see also the associated Focus). The image shows a kidney cross section from a mouse subjected to unilateral ureteral obstruction to induce kidney damage that has been labeled for endothelial (green) and mesenchymal (red) cell markers and nuclei (blue). [Image: Lovisa et al./Science Signaling]
