Contents
16 June 2020
Vol 13, Issue 636
Vol 13, Issue 636
Research Articles
- Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues
Solving the structure of the hinge domain of an epigenetic regulator highlights residues involved in dimerization and function.
- High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors
Effective treatments might be identified by rapidly profiling drug sensitivities in patient biopsies from solid tumors.
Editors' Choice
- Revealing the plasma membrane in GPCR signaling
The structure of a membrane-embedded, activated D2 dopamine receptor will help in the development of more selective therapeutics.
About The Cover
Online Cover This week features a Research Article that presents the structure of the hinge domain of the epigenetic regulator SMCHD1 and identifies amino acid residues involved in protein dimerization and function. The image shows the hinge domain structures of two SMCHD1 subunits (blue and peach) interacting with DNA (green). [Image: Jeroen Claus/Phospho Biomedical Animation]
