23 June 2020
Vol 13, Issue 637

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that Ca2+ flux mediated by the lysosomal channel TRPML1 initiates the Ca2+ sparks generated by ryanodine receptors (RyRs) that control arterial contractility and blood pressure (see also the associated Focus). The image shows smooth muscle cells from mouse contractile cerebral artery that have been fluorescently labeled for RyR2 (cyan) and the lysosomal marker Lamp-1 (magenta). [Image: Thakore et al./Science Signaling]