Contents
23 June 2020
Vol 13, Issue 637
Vol 13, Issue 637
Focus
- TRPML1ng on sparks
The lysosomal channel TRPML1 acts as the trigger for Ca2+ sparks that promote arterial relaxation (Thakore et al., in 23 June 2020 issue).
Research Articles
- TRPML1 channels initiate Ca2+ sparks in vascular smooth muscle cells
Ca2+ sparks that control arterial contractility and blood pressure require the lysosomal channel TRPML1.
- A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration
Enzymatic and nonenzymatic functions of Rac1 promote the growth and metastasis of MET-driven tumors.
Editors' Choice
- Sleepless with ROS
Sleep deprivation may kill because it induces ROS accumulation and increased oxidative stress in the gut.
About The Cover
Online Cover This week features a Research Article that shows that Ca2+ flux mediated by the lysosomal channel TRPML1 initiates the Ca2+ sparks generated by ryanodine receptors (RyRs) that control arterial contractility and blood pressure (see also the associated Focus). The image shows smooth muscle cells from mouse contractile cerebral artery that have been fluorescently labeled for RyR2 (cyan) and the lysosomal marker Lamp-1 (magenta). [Image: Thakore et al./Science Signaling]
