FocusCalcium signaling

TRPML1ng on sparks

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Science Signaling  23 Jun 2020:
Vol. 13, Issue 637, eabc0993
DOI: 10.1126/scisignal.abc0993

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Abstract

In this issue of Science Signaling, Thakore et al. report that the Ca2+-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca2+ sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.

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