Contents
07 July 2020
Vol 13, Issue 639
Vol 13, Issue 639
Research Articles
- BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1
BMP-1–mediated cleavage of TSP-1 reduces cell adhesion and promotes TGF-β signaling.
- Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity
The catalytic activity of multiple Ser/Thr kinases is regulated through a conserved Cys-based redox mechanism.
- A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily
Evolutionarily conserved cysteine residues mediate the sensitivity of the metabolic kinase FN3K to shifts in redox status.
Editors' Choice
- Fat cells help wounds heal
Dermal adipocytes promote wound healing by recruiting macrophages and transdifferentiating into myofibroblasts.
About The Cover
Online Cover This week features a Research Article that demonstrates that cleavage of the matricellular protein TSP-1 by the protease BMP-1 reduces cell adhesion and promotes TGF-β signaling. The image shows a cross-section of a mouse cornea stained to show the myofibroblast marker α-smooth muscle actin in red. [Image: Anastasi et al./Science Signaling]
