Contents
14 July 2020
Vol 13, Issue 640
Vol 13, Issue 640
Focus
- Untangling the ties that bind different systemic signals in plants
Glutamate receptors integrate wound-induced signals to propagate systemic responses in plants (Shao et al., in 14 July 2020 issue).
Research Articles
- Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival
Mitochondrial Ca2+ influx promotes oxidative phosphorylation–independent pathways to enable cancer cell survival.
- Two glutamate- and pH-regulated Ca2+ channels are required for systemic wound signaling in Arabidopsis
The propagation of systemic wound signals in plants requires pH-sensitive, Ca2+-permeable glutamate receptors.
- Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis
Multiple critical pairs of residues in the chemokine CXCL12 and its receptor CXCR4 mediate receptor activation and signaling.
Editors' Choice
- New connections: Flux and distance in Ca2+ signaling
Understanding ER-to-mitochondrial Ca2+ flux may provide ways to correct mitochondrial dysfunction in various diseases.
About The Cover
Online Cover This week features a Research Article that shows that systemic wound signaling in the model plant Arabidopsis thaliana requires pH-sensitive, Ca2+-permeable glutamate receptors. (See also the associated Focus.) The image shows intracellular Ca2+ release (green) in the stems and leaves of an Arabidopsis plant after wounding of the main root. [Image: Shao et al./Science Signaling]
