Research ArticlePlant biology

Two glutamate- and pH-regulated Ca2+ channels are required for systemic wound signaling in Arabidopsis

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Science Signaling  14 Jul 2020:
Vol. 13, Issue 640, eaba1453
DOI: 10.1126/scisignal.aba1453

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Glutamate-dependent systemic signaling in plants

Upon wounding, plants generate systemic Ca2+ waves and electrical signals that propagate from the wound site to distal tissues (see the Focus by Fichman et al.). The glutamate receptor–like proteins GLR3.3 and GLR3.6 are required for leaf-to-leaf systemic wound signals in Arabidopsis thaliana. Shao et al. found that wounding or the application of glutamate induced root-to-shoot Ca2+ and electrical signaling in Arabidopsis, which required GLR3.3, GLR3.6, and inhibition of the proton pump AHA1. In cultured mammalian cells, GLR3.3 and GLR3.6 functioned as pH-sensitive, glutamate-gated Ca2+ channels. These findings suggest that wounding induces both the leakage of glutamate from the phloem into the apoplastic space and an increase in the apoplastic pH, leading to the activation of GLRs and the generation of systemic Ca2+ waves and electrical signals.

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