Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

Michael A. Casasanta; Christopher C. Yoo; Barath Udayasuryan; Blake E. Sanders; Ariana Umaña; Yao Zhang; Huaiyao Peng; Alison J. Duncan; Yueying Wang; Liwu Li; Scott S. Verbridge; Daniel J. Slade

doi:10.1126/scisignal.aba9157

Research ArticleHost-Microbe Interactions

Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

View ORCID ProfileMichael A. Casasanta¹,*,
View ORCID ProfileChristopher C. Yoo¹,*,
View ORCID ProfileBarath Udayasuryan²,*,
View ORCID ProfileBlake E. Sanders¹,
View ORCID ProfileAriana Umaña¹,
View ORCID ProfileYao Zhang³,
View ORCID ProfileHuaiyao Peng²,
View ORCID ProfileAlison J. Duncan¹,
View ORCID ProfileYueying Wang¹,
View ORCID ProfileLiwu Li ³,
View ORCID ProfileScott S. Verbridge ², and
View ORCID ProfileDaniel J. Slade ¹,†

¹Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
²Laboratory of Integrative Tumor Ecology, and Virginia Tech–Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.
³Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

↵†Corresponding author. Email: dslade{at}vt.edu

↵* These authors contributed equally to this work.

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Science Signaling 21 Jul 2020:
Vol. 13, Issue 641, eaba9157
DOI: 10.1126/scisignal.aba9157

Michael A. Casasanta

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Christopher C. Yoo

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Barath Udayasuryan

2Laboratory of Integrative Tumor Ecology, and Virginia Tech–Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.

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Blake E. Sanders

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Ariana Umaña

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Yao Zhang

3Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Huaiyao Peng

2Laboratory of Integrative Tumor Ecology, and Virginia Tech–Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.

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Alison J. Duncan

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Yueying Wang

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Liwu Li

3Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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Scott S. Verbridge

2Laboratory of Integrative Tumor Ecology, and Virginia Tech–Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.

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Daniel J. Slade

1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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For correspondence: dslade@vt.edu

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vol. 13 no. 641

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https://doi.org/10.1126/scisignal.aba9157

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Received January 15, 2020
Accepted May 19, 2020
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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

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