Research ResourceHost-Microbe Interactions

A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis

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Science Signaling  28 Jul 2020:
Vol. 13, Issue 642, eabb0443
DOI: 10.1126/scisignal.abb0443

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The brain on probiotics

Besides being a key player in the regulation of host metabolism and immunity, the gut microbiome also plays an important role in the gut-brain axis, a system of bidirectional communication between the central and enteric nervous systems. Zhang et al. analyzed the brain peptidomes and gut microbiomes of mice fed two different species of probiotics. Probiotic treatment altered the abundances of many neuropeptides in a manner that correlated with changes in the composition of the gut microbiome, varied by brain region, and depended on the probiotic species, whether the probiotic was live or heat-killed, and the duration of treatment. These omics datasets are a foundation for future studies of the mechanistic links between the gut microbiota and cognitive, behavioral, and physiological processes controlled by neuropeptides.

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