Contents
04 August 2020
Vol 13, Issue 643
Vol 13, Issue 643
Research Articles
- An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease
A platform for comparing trans-omics datasets between IBD mouse models and human patients reveals therapeutically relevant targets.
- The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid
Multiple receptors on platelets drive Alzheimer’s disease–associated amyloid deposits in brain vessels.
- Structural insights into the signal transduction mechanism of the K+-sensing two-component system KdpDE
The DNA binding domain contributes to the specific interaction between members of a two-component system.
Editors' Choice
- Coordinating a neutrophil swarm
Ca2+ and ATP signaling control the self-organized, collective behaviors of neutrophils at wound sites.
About The Cover
Online Cover This week features a Research Article that demonstrates an approach to combine proteomic data from mouse models with transcriptomic data from human patients with inflammatory bowel disease, such as Crohn's disease. This analysis led to the identification of a signaling pathway responsible for resistance to a standard therapy. The image is a light micrograph of a section through an intestine in the early stages of Crohn's disease. [Image: Steve Gschmeissner/Science Source]
