Research ArticlePhysiology

The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid

See allHide authors and affiliations

Science Signaling  04 Aug 2020:
Vol. 13, Issue 643, eaba9872
DOI: 10.1126/scisignal.aba9872

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Unclogging amyloid from arteries

Cerebral amyloid angiopathy (CAA) is a common feature of Alzheimer’s disease in which the deposition of amyloid in vessels in the brain impairs blood flow. Amyloid can activate platelets, which promotes amyloid aggregation. Using platelets from patients and mice, Donner et al. found that blocking the collagen receptor GPVI may reduce CAA. Amyloid bound to GPVI on platelets and stimulated the release of fibrinogen that both clustered with soluble amyloid and bound a platelet-surface integrin that further promoted amyloid aggregation. Blockade of GPVI or the integrin reduced amyloid aggregation in platelet cultures, and loss of GPVI reduced the adhesion of amyloid-activated platelets in arteries in mice, revealing a potential therapeutic target to ameliorate CAA in patients.

View Full Text

Stay Connected to Science Signaling