Contents
11 August 2020
Vol 13, Issue 644
Vol 13, Issue 644
Focus
- Bacterial invaders drive CRC progression
Gut-resident fusobacteria induce tumor-intrinsic chemotaxis in colon cancer (Casasanta et al., in 21 July 2020 issue).
Research Articles
- Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice
Targeting a phosphosite in the kinase PERK may protect neurons and avoid toxicity in prion disease.
- Oxidative cross-linking of fibronectin confers protease resistance and inhibits cellular migration
Cross-linking of fibronectin occurs under inflammatory and profibrotic conditions and impairs cell migration.
Editors' Choice
- A better workout without PHD3
PHD3 deficiency increases fatty acid oxidation in skeletal muscle and improves endurance exercise performance.
About The Cover
Online Cover This week features a Research Article that shows how promoting the phosphorylation of a substrate-binding motif in the kinase PERK can reduce neuronal loss from prion infection in the brain without causing the pancreatic damage seen with conventional PERK inhibitors. The image is a transmission electron micrograph of prion protein fibrils. [Image: Scott Camazine/Science Source]
