Contents

Research Articles

• Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

  By Suhas S. Kharat, Xia Ding, Divya Swaminathan, Akshey Suresh, Manish Singh, Satheesh K. Sengodan, Sandra Burkett, Hanna Marks, Chinmayi Pamala, Yafeng He, Stephen D. Fox, Eugen C. Buehler, Kathrin Muegge, Scott E. Martin, Shyam K. Sharan

  Science Signaling18 Aug 2020 Full AccessRestricted Access

  Loss of DNA demethylase TET2 protects stalled replication forks from degradation and confers chemoresistance.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma

  By Masamichi Hayashi, Elisa Guida, Yoshikuni Inokawa, Rachel Goldberg, Leonardo O. Reis, Akira Ooki, Manohar Pilli, Pritam Sadhukhan, Juhyung Woo, Woonyoung Choi, Evgeny Izumchenko, Leonel Maldonado Gonzalez, Luigi Marchionni, Alex Zhavoronkov, Mariana Brait, Trinity Bivalacqua, Alexander Baras, George J. Netto, Wayne Koch, Anju Singh, Mohammad O. Hoque

  Science Signaling18 Aug 2020 Full AccessRestricted Access

  GULP1 silencing increases NRF2-mediated antioxidant signaling that promotes urothelial carcinoma growth.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics

  By Anatoly Kiyatkin, Iris K. van Alderwerelt van Rosenburgh, Daryl E. Klein, Mark A. Lemmon

  Science Signaling18 Aug 2020 Full AccessRestricted Access

  ERK signaling dynamics that determine cell fate decisions are encoded by RTK activation kinetics.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials