Contents
Vol 13, Issue 645
Research Articles
- Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability
Loss of DNA demethylase TET2 protects stalled replication forks from degradation and confers chemoresistance.
- GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma
GULP1 silencing increases NRF2-mediated antioxidant signaling that promotes urothelial carcinoma growth.
- Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics
ERK signaling dynamics that determine cell fate decisions are encoded by RTK activation kinetics.
Editors' Choice
- A prosocial neuroligin
NLGN3 links oxytocin signaling, protein synthesis, and social behavior in a mouse model of autism.
About The Cover

Online Cover This week features a Research Article that finds that the DNA demethylase TET2 mediates sensitivity to PARP inhibitors by promoting the degradative processing of stalled replication forks. The image shows a chromosome spread from U2OS cells overexpressing TET2 and treated with hydroxyurea. [Image: S. Burkett/National Cancer Institute, USA]