Contents
25 August 2020
Vol 13, Issue 646
Vol 13, Issue 646
Research Articles
- Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice
The blastocyst-induced release of ATP by uterine epithelial cells stimulates decidualization and implantation in mice.
- An allosteric site on MKP5 reveals a strategy for small-molecule inhibition
A small-molecule inhibitor of the phosphatase MKP5 identifies an allosteric site that enables specific targeting.
Editors' Choice
- Growth factors and SARS-CoV-2
Phosphoproteomics analysis reveals that blocking growth factor receptor signaling inhibits SARS-CoV-2 replication.
About The Cover
Online Cover This week features a Research Article reporting that mouse blastocysts prepare the uterus for implantation by stimulating uterine epithelial cells to release ATP, which triggers the endometrium to undergo decidualization, a process that is necessary for pregnancy and placental formation. The image shows a section of mouse uterus from the third day of pregnancy stained for the ATP receptor P2Y2 (green) and nuclei (red). [Image: Gu et al./Science Signaling]
