Contents

Research Articles

• µ-Opioid receptor–induced synaptic plasticity in dopamine neurons mediates the rewarding properties of anabolic androgenic steroids

  By Leonardo Bontempi, Antonello Bonci

  Science Signaling01 Sep 2020 Full AccessRestricted Access

  Induction of opioid signaling in a “reward center” of the brain underlies the addictive nature of anabolic steroids.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban

  By Julia Menzel, Daniel Kownatzki-Danger, Sergiy Tokar, Alice Ballone, Kirsten Unthan-Fechner, Markus Kilisch, Christof Lenz, Henning Urlaub, Mattia Mori, Christian Ottmann, Michael J. Shattock, Stephan E. Lehnart, Blanche Schwappach

  Science Signaling01 Sep 2020 Full AccessRestricted Access

  Phosphorylation alters how phospholamban binds to 14-3-3 and affects cardiomyocyte Ca²⁺ signaling.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas

  By Arturo Carabias, María Gómez-Hernández, Sergio de Cima, Antonio Rodríguez-Blázquez, Alba Morán-Vaquero, Patricia González-Sáenz, Carmen Guerrero, José M. de Pereda

  Science Signaling01 Sep 2020 Full AccessRestricted Access

  Cancer-associated mutations in the GEF C3G may promote lymphoma progression by activating the GTPase Rap1.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials