Contents
Vol 13, Issue 647
Research Articles
- µ-Opioid receptor–induced synaptic plasticity in dopamine neurons mediates the rewarding properties of anabolic androgenic steroids
Induction of opioid signaling in a “reward center” of the brain underlies the addictive nature of anabolic steroids.
- 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban
Phosphorylation alters how phospholamban binds to 14-3-3 and affects cardiomyocyte Ca2+ signaling.
- Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas
Cancer-associated mutations in the GEF C3G may promote lymphoma progression by activating the GTPase Rap1.
Editors' Choice
- Flipping an exosome switch
Nutrient stress changes the biogenesis and biological activity of exosomes in cancer cells.
About The Cover

Online Cover This week features a Research Article that shows that endogenous opioid signaling in a dopaminergic reward center of the brain underlies the addictive nature of anabolic steroids. The image shows a filled syringe in a gym setting. [Image: Shutterstock]