Contents
15 September 2020
Vol 13, Issue 649
Vol 13, Issue 649
Editorial
- COVID-19: All the wrong moves in all the wrong places
Missteps and opportunities in the tackling of the COVID-19 pandemic are discussed.
Research Article
- PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
PD-1 signaling suppresses tumor-infiltrating lymphocytes by destabilizing their interactions with target tumor cells.
- Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses
An IL-10 variant with higher affinity for a receptor subunit remains effective at low concentrations.
Research Resource
- Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway
A genetic screen in haploid human cells reveals context-specific regulators of the mTORC1 pathway.
Editors' Choice
- Linking integrins and EVs in metastasis
Integrins mediate the uptake of extracellular vesicles into breast cancer cells.
About The Cover
Online Cover This week features a Research Article that shows that signaling by the inhibitory receptor PD-1 on tumor-infiltrating lymphocytes interferes with their ability to form stable contacts with their target tumor cells, thus impairing tumor cell killing. The image is a scanning electron micrograph of a tumor showing tumor cells (red), blood vessels (yellow), and tumor-infiltrating lymphocytes (white). [Image: Eye of Science/Science Source]
