Contents
06 October 2020
Vol 13, Issue 652
Vol 13, Issue 652
Research Articles
- Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms
Altering the relative abundance of progesterone receptor isoforms drives ovarian neoplasia in mice.
- Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells
Macrophage-secreted TGF-β promotes glycolysis in tumor cells to support angiogenesis and immunosuppression.
Editors' Choice
- Feeling the warmth in your bones
Warm ambient temperatures induce gut microbiota to release factors that limit bone loss.
About The Cover
Online Cover This week features a Research Article that shows that altering the relative abundance of the progesterone receptor isoforms PgrA and PgrB in mice causes ovarian cancer, suggesting that similar imbalances observed in reproductive tract cancers in women may drive tumorigenesis. The image shows a hematoxylin and eosin–stained section of a neoplastic ovary from a mouse overexpressing PgrB in the reproductive tract. [Image: F. J. DeMayo/NIEHS]
