Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

Valentí Gómez; Thomas R. Eykyn; Rami Mustapha; Fabián Flores-Borja; Victoria Male; Paul R. Barber; Antonia Patsialou; Ryan Green; Fani Panagaki; Chun W. Li; Gilbert O. Fruhwirth; Susana Ros; Kevin M. Brindle; Tony Ng

doi:10.1126/scisignal.aax4585

Research ArticleCancer Immunology

Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

View ORCID ProfileValentí Gómez¹,*,
View ORCID ProfileThomas R. Eykyn²,
View ORCID ProfileRami Mustapha³,
View ORCID ProfileFabián Flores-Borja ⁴,
View ORCID ProfileVictoria Male⁵,
View ORCID ProfilePaul R. Barber¹,
Antonia Patsialou¹,
Ryan Green⁴,
Fani Panagaki²,
View ORCID ProfileChun W. Li²,
View ORCID ProfileGilbert O. Fruhwirth²,
View ORCID ProfileSusana Ros⁶,
View ORCID ProfileKevin M. Brindle⁶, and
View ORCID ProfileTony Ng ¹,³,⁴,*

¹UCL Cancer Institute, University College London, London WC1E 6DD, UK.
²School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
³School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.
⁴KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.
⁵Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London NW3 2QG, UK.
⁶Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

↵*Corresponding author. Email: tony.ng{at}kcl.ac.uk (T.N.), valentin.gomez{at}ucl.ac.uk (V.G.)

See allHide authors and affiliations

Science Signaling 06 Oct 2020:
Vol. 13, Issue 652, eaax4585
DOI: 10.1126/scisignal.aax4585

Valentí Gómez

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Valentí Gómez
For correspondence: tony.ng@kcl.ac.uk valentin.gomez@ucl.ac.uk

Thomas R. Eykyn

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Thomas R. Eykyn

Rami Mustapha

3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rami Mustapha

Fabián Flores-Borja

4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fabián Flores-Borja

Victoria Male

5Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London NW3 2QG, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Victoria Male

Paul R. Barber

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Paul R. Barber

Antonia Patsialou

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ryan Green

4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Fani Panagaki

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chun W. Li

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chun W. Li

Gilbert O. Fruhwirth

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gilbert O. Fruhwirth

Susana Ros

6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Susana Ros

Kevin M. Brindle

6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kevin M. Brindle

Tony Ng

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.

4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tony Ng
For correspondence: tony.ng@kcl.ac.uk valentin.gomez@ucl.ac.uk

Article
Figures & Data
Info & Metrics
eLetters
PDF

Article Information

vol. 13 no. 652

DOI:

https://doi.org/10.1126/scisignal.aax4585

PubMed:

Published By:

Print ISSN:

Online ISSN:

History:

Received March 26, 2019
Resubmitted April 23, 2020
Accepted August 26, 2020
.

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

Author Information

Altmetric

Article usage

Article usage: October 2020 to March 2021

	Abstract	Full	Pdf
Oct 2020	1060	5770	1023
Nov 2020	894	206	106
Dec 2020	555	230	128
Jan 2021	306	116	53
Feb 2021	341	55	33
Mar 2021	12	0	0

View Full Text

Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

Article Information

Author Information

Altmetric

Article usage

Article usage: October 2020 to March 2021

Science Signaling

Article Tools