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Research ArticleCancer Immunology
Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells
- View ORCID ProfileValentí Gómez1,*,
- View ORCID ProfileThomas R. Eykyn2,
- View ORCID ProfileRami Mustapha3,
- View ORCID ProfileFabián Flores-Borja4,
- View ORCID ProfileVictoria Male5,
- View ORCID ProfilePaul R. Barber1,
- Antonia Patsialou1,
- Ryan Green4,
- Fani Panagaki2,
- View ORCID ProfileChun W. Li2,
- View ORCID ProfileGilbert O. Fruhwirth2,
- View ORCID ProfileSusana Ros6,
- View ORCID ProfileKevin M. Brindle6, and
- View ORCID ProfileTony Ng1,3,4,*
- 1UCL Cancer Institute, University College London, London WC1E 6DD, UK.
- 2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
- 3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.
- 4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.
- 5Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London NW3 2QG, UK.
- 6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
- ↵*Corresponding author. Email: tony.ng{at}kcl.ac.uk (T.N.), valentin.gomez{at}ucl.ac.uk (V.G.)
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Science Signaling 06 Oct 2020:
Vol. 13, Issue 652, eaax4585
DOI: 10.1126/scisignal.aax4585
Vol. 13, Issue 652, eaax4585
DOI: 10.1126/scisignal.aax4585
Valentí Gómez
1UCL Cancer Institute, University College London, London WC1E 6DD, UK.
Thomas R. Eykyn
2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
Rami Mustapha
3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.
Fabián Flores-Borja
4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.
Victoria Male
5Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London NW3 2QG, UK.
Paul R. Barber
1UCL Cancer Institute, University College London, London WC1E 6DD, UK.
Antonia Patsialou
1UCL Cancer Institute, University College London, London WC1E 6DD, UK.
Ryan Green
4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.
Fani Panagaki
2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
Chun W. Li
2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
Gilbert O. Fruhwirth
2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
Susana Ros
6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
Kevin M. Brindle
6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
Tony Ng
1UCL Cancer Institute, University College London, London WC1E 6DD, UK.
3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.
4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.
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