Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

Valentí Gómez; Thomas R. Eykyn; Rami Mustapha; Fabián Flores-Borja; Victoria Male; Paul R. Barber; Antonia Patsialou; Ryan Green; Fani Panagaki; Chun W. Li; Gilbert O. Fruhwirth; Susana Ros; Kevin M. Brindle; Tony Ng

doi:10.1126/scisignal.aax4585

Research ArticleCancer Immunology

Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

View ORCID ProfileValentí Gómez¹,*,
View ORCID ProfileThomas R. Eykyn²,
View ORCID ProfileRami Mustapha³,
View ORCID ProfileFabián Flores-Borja ⁴,
View ORCID ProfileVictoria Male⁵,
View ORCID ProfilePaul R. Barber¹,
Antonia Patsialou¹,
Ryan Green⁴,
Fani Panagaki²,
View ORCID ProfileChun W. Li²,
View ORCID ProfileGilbert O. Fruhwirth²,
View ORCID ProfileSusana Ros⁶,
View ORCID ProfileKevin M. Brindle⁶, and
View ORCID ProfileTony Ng ¹,³,⁴,*

¹UCL Cancer Institute, University College London, London WC1E 6DD, UK.
²School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.
³School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.
⁴KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.
⁵Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London NW3 2QG, UK.
⁶Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

↵*Corresponding author. Email: tony.ng{at}kcl.ac.uk (T.N.), valentin.gomez{at}ucl.ac.uk (V.G.)

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Science Signaling 06 Oct 2020:
Vol. 13, Issue 652, eaax4585
DOI: 10.1126/scisignal.aax4585

Valentí Gómez

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

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For correspondence: tony.ng@kcl.ac.uk valentin.gomez@ucl.ac.uk

Thomas R. Eykyn

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

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Rami Mustapha

3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.

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Fabián Flores-Borja

4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.

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Victoria Male

5Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London NW3 2QG, UK.

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Paul R. Barber

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

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Antonia Patsialou

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

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Ryan Green

4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.

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Fani Panagaki

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

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Chun W. Li

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

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Gilbert O. Fruhwirth

2School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

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Susana Ros

6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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Kevin M. Brindle

6Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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Tony Ng

1UCL Cancer Institute, University College London, London WC1E 6DD, UK.

3School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 1UL, UK.

4KCL Breast Cancer Now Research Unit, Department of Research Oncology, Guy’s Hospital, King’s College London, London SE1 1UL, UK.

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For correspondence: tony.ng@kcl.ac.uk valentin.gomez@ucl.ac.uk

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