Contents
13 October 2020
Vol 13, Issue 653
Vol 13, Issue 653
Research Article
- Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells
Fluid pressure in the proximal tubule activates TRPV4 to promote endocytosis and retention of albumin.
Research Resource
- RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway
RASSF proteins interact with distinct GTPase partners to regulate downstream Hippo and p53 signaling.
Editors' Choice
- A healthy dose of fear
Secretion of IL-17a from meninges-resident T cells promotes anxiety-like behavior in mice.
About The Cover
Online Cover This week features a Research Article that describes how fluid pressure in the proximal tubule in the kidney activates the cation channel TRPV4 to promote endocytosis and retention of albumin. The image shows the colocalization of TRPV4 (green) with Na+/K+-ATPase (red) in renal cortical sections from wild-type mice. [Image: Gualdani et al./Science Signaling]
