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Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S

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Science Signaling  20 Oct 2020:
Vol. 13, Issue 654, eabd9892
DOI: 10.1126/scisignal.abd9892

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Abstract

Precise control of the activity and abundance of ubiquitin-conjugating enzymes (E2s) ensures fidelity in ubiquitin chain synthesis. In this issue of Science Signaling, Liess et al. demonstrate that the human anaphase-promoting complex (APC/C)–associated E2 UBE2S adopts an autoinhibited dimeric state that increases the half-life of UBE2S by preventing its autoubiquitination-driven turnover.

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