Contents
17 November 2020
Vol 13, Issue 658
Vol 13, Issue 658
Research Articles
- NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival
NF-κB signaling promotes the survival of myofibroblasts during the late stages of tendon repair.
- ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells
Blocking the antiapoptotic protein Mcl-1 sensitizes TNBC cells to erlotinib.
Editors' Choice
- MAPping PI3K signaling to endosomes
The microtubule-associated protein MAP4 recruits PI3Kα from the plasma membrane to endosomes to activate Akt signaling.
About The Cover
Online Cover This week features a Research Article that shows that NF-κB signaling promotes the survival of myofibroblasts during the late stages of tendon repair. The image shows coimmunofluorescence of phosphorylated NF-κB p65 (green), a tendon cell lineage marker (red), and nuclei (blue) in a healing mouse tendon 28 days after surgical transection. The tendon tissue is bounded by large autofluorescent muscle cells. [Image: Best et al./Science Signaling]
