Contents
01 December 2020
Vol 13, Issue 660
Vol 13, Issue 660
Research Resource
- Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity
Obesity shifts glucose-responsive hepatic metabolism from rapid regulation by metabolites to slower changes in gene expression.
Research Articles
- 2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila
The cyclic dinucleotide 2′3′-cGAMP activates STING and NF-κB to protect Drosophila against multiple viruses.
- Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases
LGR5 does not potentiate Wnt signaling by inhibiting the E3 ligases RNF43 and ZNRF3.
Editors' Choice
- Acid-addicted cells
PRL3 enables cells to tolerate acidic pH and promotes metastasis by stimulating TRPML-dependent lysosome exocytosis.
About The Cover
Online Cover This week features a Research Resource that reveals that obesity shifts glucose-responsive hepatic metabolism from rapid regulation by metabolites to slower changes in gene expression using transomics analysis of metabolites, metabolic reactions, metabolic enzymes, transcription factors, and proteins in the insulin signaling pathway. The image shows an artist's depiction of networks in the liver. [Image: Julia Kopacheva/Shutterstock]
