Contents
08 December 2020
Vol 13, Issue 661
Vol 13, Issue 661
Research Articles
- Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling
Knockout or inhibition of the channel and kinase TRPM7 increases the number of regulatory T cells in mice.
- A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses
A disproportionately large response is induced by small increases in the abundance of a pathogen sensor.
Research Resource
- A novel TNFR2 agonist antibody expands highly potent regulatory T cells
An antibody that stimulates the cytokine receptor TNFR2 activates immunosuppressive regulatory T cells.
Editors' Choice
- New connections: Restoring immune balance
New targets to expand regulatory T cell populations may be therapeutic for autoimmune and inflammatory diseases.
About The Cover
Online Cover This week features a Research Article that shows that deletion or inhibition of the channel and kinase TRPM7 in mice increased the number of regulatory T cells, which protected the mice from developing effector T cell–dependent hepatitis. The image is a light micrograph of tissue from a liver in a case of chronic hepatitis. [Image: Biophoto Associates/Science Source]
