15 December 2020
Vol 13, Issue 662

About The Cover

Cover image expansion

Online Cover This week features a Research Article that finds that the glutamate receptor mGluR5 may be a viable Alzheimer’s disease (AD) drug target only in male patients because of the sex-selective presence of cellular prion protein, which bridges the interaction between the receptor and β-amyloid. The image shows β-amyloid plaque staining in brain slices from male and female AD-model mice treated with an mGluR5 antagonist. [Image: Abd-Elrahman et al./Science Signaling]