Contents
22 December 2020
Vol 13, Issue 663
Vol 13, Issue 663
Research Article
- Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death
Akt1-activating compounds such as the polyphenol chlorogenic acid may prevent neuronal death in Parkinson’s disease.
Reviews
- Neuroligin-2 as a central organizer of inhibitory synapses in health and disease
The synaptic adhesion protein NLGN2 is integral to inhibitory neurotransmission and modulates behavior.
- Tissue-specific adrenergic regulation of the L-type Ca2+ channel CaV1.2
Adrenergic stimulation induces differential phosphorylation of CaV1.2 in brain and heart.
Editors' Choice
- The ceramide fast track to puberty
Diet-induced obesity triggers hypothalamic ceramide signaling that leads to precocious puberty in female rats.
About The Cover
Online Cover This week features a Research Article that shows how activating the kinase Akt1, such as with chlorogenic acid, prevents neuronal death in mouse models of Parkinson's disease. The image shows a micrograph of human brain tissue that shows signs of Parkinson's disease. [Image: Michael Abbey/Science Source]
