Contents
05 January 2021
Vol 14, Issue 664
Vol 14, Issue 664
Research Articles
- Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
Kidney tumors lacking fumarate hydratase become aggressive due to a metabolic shift arising from altered mitochondrial DNA.
- The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors
Two ligand-binding sites in a chemoreceptor enable a human bacterial pathogen to adapt to hosts.
About The Cover
Online Cover This week features a Research Article that shows that loss of the metabolic enzyme fumarate hydratase in an aggressive type of kidney cancer called hereditary leiomyomatosis and renal cell carcinoma (HLRCC) results in mitochondrial DNA mutations, mitochondrial depletion, and altered metabolism. The electron microscopic image shows a metastasis from an HLRCC tumor. [Image: F. Soheilian/National Cancer Institute, USA]
