05 January 2021
Vol 14, Issue 664

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that loss of the metabolic enzyme fumarate hydratase in an aggressive type of kidney cancer called hereditary leiomyomatosis and renal cell carcinoma (HLRCC) results in mitochondrial DNA mutations, mitochondrial depletion, and altered metabolism. The electron microscopic image shows a metastasis from an HLRCC tumor. [Image: F. Soheilian/National Cancer Institute, USA]