Contents
12 January 2021
Vol 14, Issue 665
Vol 14, Issue 665
Research Articles
- Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy
Peptide-binding assays suggest that SARS-CoV-2 receptors engage the endocytosis and autophagy machinery.
- Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation
Pathologic BMP signaling promotes ectopic craniofacial cartilage formation by inhibiting the breakdown of β-catenin.
Research Resource
- Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications
Cytosolic tail motifs in host cell surface receptors predict modes of SARS-CoV-2 entry and propagation.
Editors' Choice
- Respiring with H2O2
Intestinal microbes exploit host-derived H2O2 for respiration under both normal and inflammatory conditions.
About The Cover
Online Cover This week features a paired Research Resource and Research Article that analyzed peptide-binding motifs in the intracellular tails of ACE2 and β3 integrin to suggest that SARS-CoV-2 receptors engage the endocytosis and autophagy machineries. The image shows a section of a coronavirus-infected Vero E6 cell. [Image: Science Source]
