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Research ArticleDevelopmental Biology
Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation
- View ORCID ProfileJingwen Yang1,2,
- Megumi Kitami3,4,
- Haichun Pan2,
- View ORCID ProfileMasako Toda Nakamura2,
- View ORCID ProfileHonghao Zhang2,
- View ORCID ProfileFei Liu2,
- View ORCID ProfileLingxin Zhu1,5,
- Yoshihiro Komatsu3,4,*, and
- Yuji Mishina2,*
- 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
- 2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
- 3Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.
- 4Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
- 5Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
- ↵*Corresponding author. Email: yoshihiro.komatsu{at}uth.tmc.edu (Y.K.); mishina{at}umich.edu (Y.M.)
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Science Signaling 12 Jan 2021:
Vol. 14, Issue 665, eaaz9368
DOI: 10.1126/scisignal.aaz9368
Vol. 14, Issue 665, eaaz9368
DOI: 10.1126/scisignal.aaz9368
Jingwen Yang
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Megumi Kitami
3Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.
4Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
Haichun Pan
2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Masako Toda Nakamura
2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Honghao Zhang
2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Fei Liu
2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Lingxin Zhu
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
5Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Yoshihiro Komatsu
3Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.
4Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
Yuji Mishina
2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
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