Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation

Jingwen Yang; Megumi Kitami; Haichun Pan; Masako Toda Nakamura; Honghao Zhang; Fei Liu; Lingxin Zhu; Yoshihiro Komatsu; Yuji Mishina

doi:10.1126/scisignal.aaz9368

Research ArticleDevelopmental Biology

Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation

View ORCID ProfileJingwen Yang ¹,²,
Megumi Kitami³,⁴,
Haichun Pan²,
View ORCID ProfileMasako Toda Nakamura²,
View ORCID ProfileHonghao Zhang²,
View ORCID ProfileFei Liu²,
View ORCID ProfileLingxin Zhu¹,⁵,
Yoshihiro Komatsu ³,⁴,*, and
Yuji Mishina ²,*

¹The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
²Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
³Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.
⁴Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
⁵Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

↵*Corresponding author. Email: yoshihiro.komatsu{at}uth.tmc.edu (Y.K.); mishina{at}umich.edu (Y.M.)

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Science Signaling 12 Jan 2021:
Vol. 14, Issue 665, eaaz9368
DOI: 10.1126/scisignal.aaz9368

Jingwen Yang

1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

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ORCID record for Jingwen Yang

Megumi Kitami

3Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.

4Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.

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Haichun Pan

2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

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Masako Toda Nakamura

2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

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ORCID record for Masako Toda Nakamura

Honghao Zhang

2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

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ORCID record for Honghao Zhang

Fei Liu

2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

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Lingxin Zhu

5Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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ORCID record for Lingxin Zhu

Yoshihiro Komatsu

3Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.

4Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.

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For correspondence: yoshihiro.komatsu@uth.tmc.edu mishina@umich.edu

Yuji Mishina

2Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

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For correspondence: yoshihiro.komatsu@uth.tmc.edu mishina@umich.edu

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Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation

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