You are currently viewing the editor's summary.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Adapting to antigens
Cell surface T cell receptors (TCRs) are engaged by antigens, leading to T cell activation and cytokine production. Trendel et al. exposed primary human CD8+ T cells to a wide range of antigens and mathematically analyzed cellular cytokine production to determine both how T cells respond to constant antigen stimulation and the effect of down-regulation of the TCR from the cell surface. The authors showed that T cells adapted to constant antigen stimulation by stopping cytokine production even in the absence of complete TCR down-regulation. Signaling by costimulatory receptors broke this adaptation and maintained cytokine production. These results have implications for the design of chimeric antigen receptors that must maintain cellular activation to provide effective therapies.
This is an article distributed under the terms of the Science Journals Default License.
