Research ArticleImmunology

Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation

See allHide authors and affiliations

Science Signaling  19 Jan 2021:
Vol. 14, Issue 666, eaay9363
DOI: 10.1126/scisignal.aay9363

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Adapting to antigens

Cell surface T cell receptors (TCRs) are engaged by antigens, leading to T cell activation and cytokine production. Trendel et al. exposed primary human CD8+ T cells to a wide range of antigens and mathematically analyzed cellular cytokine production to determine both how T cells respond to constant antigen stimulation and the effect of down-regulation of the TCR from the cell surface. The authors showed that T cells adapted to constant antigen stimulation by stopping cytokine production even in the absence of complete TCR down-regulation. Signaling by costimulatory receptors broke this adaptation and maintained cytokine production. These results have implications for the design of chimeric antigen receptors that must maintain cellular activation to provide effective therapies.

View Full Text

Stay Connected to Science Signaling