FocusPhysiology

The double life of TLR2

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Science Signaling  19 Jan 2021:
Vol. 14, Issue 666, eabf4701
DOI: 10.1126/scisignal.abf4701

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Abstract

Innate immune function is not restricted to innate immune cells, and neither is the receptor TLR2. In this issue of Science Signaling, McCoy et al. reveal a new role of TLR2 in endothelial cells, where it promotes tumor angiogenesis, infiltration of myeloid cells, and, ultimately, cancer progression.

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