Contents
02 February 2021
Vol 14, Issue 668
Vol 14, Issue 668
Research Articles
- A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands
Weakening autoinhibition of the kinase ZAP70 leads to overactive T cells and autoimmune disease.
- Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease
Treatments that promote protein synthesis in the brain may preserve cognition in Alzheimer’s disease.
Review
- Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling
Signaling events in distinct subcellular locations determine whether MLKL mediates necroptosis.
Editors' Choice
- Activating T cells with asparagine
Extracellular asparagine stimulates Lck to promote T cell responses to cancer cells and infection.
About The Cover
Online Cover This week features a Research Article that shows that restoring protein synthesis in the brain with the drug ISRIB is neuroprotective and improves cognition in mouse models of Alzheimer’s disease (AD). The image shows β-amyloid staining in the hippocampus of AD-model mice treated with ISRIB (top) or vehicle (bottom). [Image: Oliveira et al./Science Signaling]
