02 February 2021
Vol 14, Issue 668

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that restoring protein synthesis in the brain with the drug ISRIB is neuroprotective and improves cognition in mouse models of Alzheimer’s disease (AD). The image shows β-amyloid staining in the hippocampus of AD-model mice treated with ISRIB (top) or vehicle (bottom). [Image: Oliveira et al./Science Signaling]