Contents
09 February 2021
Vol 14, Issue 669
Vol 14, Issue 669
Research Articles
- The kinetoplastid-specific phosphatase KPP1 attenuates PLK activity to facilitate flagellum inheritance in Trypanosoma brucei
Flagellum inheritance in trypanosomes requires strategically timed suppression of Polo-like kinase activity.
- Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice
Inhibition of endogenous activin A reduces heterotopic ossification and ectopic bone accumulation in mice.
Editors' Choice
- ATDC KEAPs NRF2 active
ATDC promotes pancreatic cancer progression and chemoresistance by disrupting KEAP1-mediated ubiquitylation of NRF2.
About The Cover
Online Cover This week features a Research Article that demonstrates that inheritance of the flagellum in Trypanosoma brucei, which is critical for virulence, requires strategically timed suppression of Polo-like kinase activity. The image is an electron micrograph that shows trypanosomes at various stages before and during cytokinesis with the original flagellum highlighted in pink and the newly synthesized flagellum highlighted in green. [Image: Ziyin Li/University of Texas Health Science Center at Houston, USA].
